ZYMOX®

ZYMOX® Ear Solution is easy to use and has been shown to work when antibiotics have failed

Got a dog with chronic ear infections and want a no-pre-cleaning enzyme ear solution?

Reviewed by Ann Pruitt, InfoHorse.com · Updated April 2026

ZYMOX®

ZYMOX® Ear Solution by Pet King Brands
ZYMOX Ear Solution requires no pre-cleaning of the ear! ZYMOX® Ear Solution is easy to use and has been shown to work when antibiotics have failed.

What Makes Pet King Brands, Makers of ZYMOX® Different?

Pet King Brands was started in 1998 by president and company visionary, Pamela Bosco and includes several products for pet dermatology and oral care. All of the products share a patented formulation of antimicrobial enzymes developed by Bosco's talented bioscientist brother, Michael Pellico. The LP3 Enzyme System is a combination of naturally occuring enzymes which work synergistically to form their antibacterial and antifungal properties and aid in the health of a pet’s ears, skin and mouth. The reigning flagship products continues to be the ZYMOX Ear products. Over the years, additional products have been introduced to meet the needs of pet owners seeking products without harsh chemicals or antibiotics and their availablity has been expanded to now include select pet retailers.

Relief Has Arrived— For Owners as Well as Dogs!
ZYMOX® not only brings relief to pets but to their owners as well. Nothing hurts a dog owner more than seeing their beloved dog suffer. Over time, chronic infections can be time-consuming, frustrating and extremely costly to a pet owner. ZYMOX®'s proven product line utilizes the LP3 Enzyme System for long-term maintenance and prevention of chronic ear and skin infections. These easy to use topical dermatology products are convenient, safe and effective.

Why Are Enzymes Better?

Enzymes are naturally occurring proteins that increase the rate of chemical reactions. They are natural defenses against harmful microbes. They can be found in many places and have very specific jobs. Enzymes won’t irritate a pet’s sensitive or raw skin, are very safe, non toxic for pets, people and the environment and most importantly, bacteria won’t develop resistance against enzymes, so they are always efficient. The patented LP3 Enzyme System in Zymox is a combination of enzymes with very specific jobs which work synergistically to inhibit, split and destroy the offending bacteria, fungi and even some viruses making the combination antibacterial as well as antifungal. The enzymes only target the invading single-celled organisms, healthy cells are unaffected.

Note: Zymox Ear Solution Is The First—and Only—NO Clean, Once A DAY Care for Ears!!

ZYMOX® Enzymatic Ear Solution

ZYMOX® Enzymatic Ear Solution aids in the management of bacterial, fungal and yeast infections including Staphylococcus, Pseudomonas, and Malassezia. The solution works with the body to react with present pus, debris and exudeate to eradicate infectious microorganisms. The non-invasive protocol requires no cleaning before and during use so that the enzyme activity is not disrupted.

Contains no antibiotics
No pre-clean, once a day protocol makes it simple to use
Prevention and management made easy
ZYMOX® Ear Cleanser

Zymox® Ear Cleanser provides an effective, non-toxic way to manage dirty ears. The addition of Lacoperoxidase, Lactoferrin and Lysozyme, which have natural bio-active properties for mild microbe control, plus gentle cleaning surfactants, makes ZYMOX® Ear Cleanser perfect for cleaning dirty ears. Does not contain harsh chemicals or detergents, which can irritate sensitive ears. Leaves ears smelling fresh…only
This is NOT your average Ear Cleaner!

What Do People Say Who Have Used Zymox®?

Zymox® Ear Solution is truly an amazing product, Thank YOU, Thank YOU, Thank YOU! —S. Gross Bergenfield, NJ

My dog asked me: Dog gonnit Mamma, why didn't you get this sooner??? Best ear cleanser I've gotten for the money.
—L. Surprenant Wakefield, NH

Don’t Let Your Dog Suffer a Minute Longer! Buy Zymox Today!

Ears are vital to the health and well being of your dog. Hot, itchy, smelly ears are signs of a problem that needs to be dealt with— and Zymox Ear Solution is the product to do it. You’ll love the affordability, the ease of use, but best of all, you’ll love the way it makes your dog feel— and look! Zymox Ear Solution is available at DrsFosterandSmith.com, JeffersPet, HorseHealthUSA, and distributors across the country!

What is the LP3 Enzyme System inside every ZYMOX product?

At the core of every ZYMOX® and Oratene® product is the patented LP3 Enzyme System, an enzyme-based technology that has been refined for over 40 years. It pairs three naturally derived enzymes that work synergistically to provide antimicrobial protection against harmful bacteria, fungi, and viruses. Because the enzymes target only harmful single-celled organisms, the LP3 system preserves the natural balance of your pet's body and minimizes the risk of bacterial resistance that is increasingly common with antibiotic treatments. This is why ZYMOX is positioned as a trusted, antibiotic-free alternative for ear, skin, and oral conditions.

ZYMOX Otic enzymatic ear solution for dogs and cats ear infections

Which three enzymes do the antimicrobial work?

The LP3 system relies on a precise enzyme trio, each sourced from nature. Lactoperoxidase, found in milk, works with hydrogen peroxide and other natural compounds to disrupt the metabolic processes of harmful bacteria. Lysozyme, sourced from egg whites, attacks bacterial cell walls and breaks them apart to kill the bacteria. Lactoferrin binds to iron, starving harmful bacteria and fungi of the iron they need to reproduce and spread. Together these enzymes form a potent defense that is effective against both bacteria and fungi without harsh chemicals.

ZYMOX Advanced Enzymatic Ear Wipes for routine pet ear care

Who makes ZYMOX, and what is the company's origin story?
ZYMOX is made by Pet King Brands, now operating as PKB Animal Health Inc., founded in 1998 by President and visionary Pamela K. Bosco. The inspiration was Elizabeth, a German Shepherd who suffered from chronic ear infections; alongside her brother, bioscientist Michael Pellico, Bosco developed the first enzyme-based pet health care products at a time when antibiotic resistance was a growing concern. The company is headquartered at 8727 Shoal Creek Blvd., Austin, TX 78757, and its products are proudly made in the USA. For over 25 years, ZYMOX and Oratene Brushless Oral Care have been trusted by veterinarians and pet owners worldwide.

ZYMOX enzymatic skin care topical cream and spray for itchy irritated pet skin

Why does ZYMOX Ear Solution require no pre-cleaning?

Traditional ear treatments often demand rigorous pre-cleaning that can cause unnecessary stress for pets already in pain. The LP3 enzymes actually thrive in environments where organic matter like pus or wax is present, which enhances their antimicrobial activity rather than being hindered by it. That means you can skip the cleaning step entirely, resulting in fewer touches, less pain, and less anxiety for your pet. Most ZYMOX products only need to be applied once a day, making it easier for owners to stay consistent and improve outcomes.

What does the full ZYMOX product line cover?

Beyond the flagship ear solutions, ZYMOX builds the LP3 Enzyme System into care for every area that commonly needs relief. Ear Care includes the ZYMOX Otic Enzymatic Solution with 1% Hydrocortisone (1.25 oz, $28.49), the ZYMOX Advanced Formula Otic Plus with 1% Hydrocortisone ($33.49), ZYMOX Advanced Enzymatic Ear Wipes ($16.99), and a dedicated ZYMOX Enzymatic Ear Solution with .5% Hydrocortisone for Cats & Kittens ($22.49). The lineup extends into Skin Care topical creams, sprays, medicated shampoos and leave-on conditioners, plus Oratene Brushless Oral Care and an Equine line — all built on the same enzyme technology.

Who is ZYMOX for, and how do you buy it?
ZYMOX is formulated for dogs, cats, kittens, puppies, and even horses, and because the enzymes are non-reactive, natural, and non-toxic, they are safe for daily, long-term use on sensitive skin and recurring conditions like allergies. The brand is endorsed by veterinary professionals and recommended for ear infections, itchy irritated skin, and oral health. Shop directly at zymox.com, use the Where to Buy store and vet locators, or find ZYMOX through major online retailers; questions go to Pet King Brands at (toll free) or, Mon-Fri 8:30-4:30PM CST.

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The Solution Section (FAQ)

What makes ZYMOX different from other options?

Over the years, additional products have been introduced to meet the needs of pet owners seeking products without harsh chemicals or antibiotics and their availablity has been expanded to now include select pet retailers.

How do you use ZYMOX?

ZYMOX Ear Solution is easy to use and has been shown to work when antibiotics have failed. About Pet King Brands, Makers of ZYMOX Pet King Brands was started in 1998 by president and company visionary, Pamela Bosco and includes several products for pet dermatology and oral care.

How did ZYMOX get started?

About Pet King Brands, Makers of ZYMOX Pet King Brands was started in 1998 by president and company visionary, Pamela Bosco and includes several products for pet dermatology and oral care.

What is ZYMOX Ear Solution and what is it used for?

ZYMOX Ear Solution is an enzymatic ear treatment made by Pet King Brands for dogs and cats. It uses the patented LP3 Enzyme System to soothe and manage bacterial, fungal (yeast), and viral ear infections. It is positioned as an antibiotic-free alternative and has been shown to work even when antibiotics have failed.

Why does ZYMOX Ear Solution require no pre-cleaning of the ear?

The LP3 enzymes actually thrive in environments where organic matter like pus or wax is present, which enhances their antimicrobial activity. Because of this, you do not need to clean the ear first. Skipping the cleaning step means fewer touches, less pain, and less anxiety for a pet that already has a sore, infected ear.

What is the LP3 Enzyme System?

The LP3 Enzyme System is the patented enzyme technology at the core of every ZYMOX and Oratene product, refined for over 40 years. It combines three naturally derived enzymes that work synergistically to provide antimicrobial protection. The system targets only harmful, single-celled organisms while leaving healthy flora and cells undisturbed.

Which three enzymes are in ZYMOX products?

The trio is lactoperoxidase, lysozyme, and lactoferrin. Lactoperoxidase (found in milk) works with hydrogen peroxide to disrupt bacterial metabolism; lysozyme (from egg whites) breaks apart bacterial cell walls; and lactoferrin binds iron to starve harmful bacteria and fungi. Together they form a defense effective against both bacteria and fungi.

Is ZYMOX an antibiotic?

No. ZYMOX is specifically designed as an antibiotic-free alternative. Unlike antibiotics, which can disrupt healthy flora and cause side effects, the LP3 enzymes target only harmful single-celled organisms. This precision also minimizes the risk of bacterial resistance that is increasingly common with antibiotic use.

Who makes ZYMOX?

ZYMOX is made by Pet King Brands, which now operates as PKB Animal Health Inc. The company was founded in 1998 and is headquartered at 8727 Shoal Creek Blvd., Austin, TX 78757. Its products are proudly made in the USA and are also the makers of the Oratene oral care line.

What inspired the creation of ZYMOX?

The company was inspired by Elizabeth, a German Shepherd who suffered from chronic ear infections. Her struggle led founder Pamela K. Bosco and her brother, bioscientist Michael Pellico, to develop the first enzyme-based pet health care products. They introduced the LP3 Enzyme System at a time when antibiotic resistance was a growing concern.

Who founded Pet King Brands?

Pet King Brands was started in 1998 by its president and company visionary, Pamela K. Bosco. She developed the original enzyme-based products together with her brother, bioscientist Michael Pellico. Bosco now resides in Austin, Texas, where her ranch serves as a sanctuary for dogs, cats, horses, and cattle.

Is ZYMOX safe for daily, long-term use?

Yes. Because the LP3 enzymes are non-reactive, natural, and non-toxic, ZYMOX products are safe for daily use, even on sensitive skin or recurring conditions like allergies. The products work at a cellular level to eliminate harmful organisms while remaining gentle on a pet's skin and coat, making them suitable for long-term, repeat use.

What ZYMOX ear products are available?

The ear care lineup includes ZYMOX Otic Enzymatic Solution with 1% Hydrocortisone (1.25 oz, $28.49), ZYMOX Advanced Formula Otic Plus with 1% Hydrocortisone ($33.49), ZYMOX Advanced Enzymatic Ear Wipes ($16.99), and a ZYMOX Enzymatic Ear Solution with .5% Hydrocortisone formulated for Cats & Kittens ($22.49). There are also hydrocortisone-free and ear cleanser options.

What is the difference between ZYMOX with and without hydrocortisone?

Both versions share the same LP3 enzyme base of lactoperoxidase, lysozyme, and lactoferrin. The hydrocortisone formulas (such as 1% or 0.5%) add a mild steroid to relieve itching, inflammation, and irritation associated with the infection. The hydrocortisone-free version is chosen when added itch relief is not needed or not desired.

Can ZYMOX be used on cats and kittens?

Yes. ZYMOX offers a dedicated Cats & Kittens line, including an Enzymatic Ear Solution with .5% Hydrocortisone formulated specifically for them ($22.49). The brand is also endorsed by TICA (The International Cat Association), reflecting its suitability for feline ear and skin care.

Does ZYMOX only make ear products?

No. The LP3 Enzyme System is built into a full range of products: ear solutions, wipes and cleansers; skin care topical creams and sprays; medicated shampoos and leave-on conditioners; Oratene Brushless Oral Care for teeth and gums; and an Equine Defense line for horses. They cover every area that commonly needs infection relief — ears, skin and coat, and the mouth.

Is ZYMOX recommended by veterinarians?

Yes. For over 25 years ZYMOX has been trusted by veterinarians and animal lovers, and its products were developed in collaboration with veterinarians to ensure safe, effective care. The company highlights that its antibiotic-free solutions help vets deliver effective care, strengthen client trust, and improve patient outcomes.

How do I use ZYMOX Ear Solution?

ZYMOX is designed to be simple: there is no pre-cleaning required, and most ZYMOX products only need to be applied once a day. You simply apply the solution into the affected ear and let the LP3 enzymes go to work. This once-daily, low-stress regimen improves compliance and is easier to maintain consistently than treatments requiring repeated cleaning.

Where can I buy ZYMOX and how do I contact the company?

You can buy ZYMOX directly at zymox.com or use the site's Where to Buy store locator, online-retailer list, and vet locator; it is also widely available through major online pet retailers. For questions, contact Pet King Brands / PKB Animal Health Inc. at 888.752.5487 (toll free) or 630.241.3905, Monday-Friday 8:30-4:30PM CST, or by mail at 8727 Shoal Creek Blvd., Austin, TX 78757.