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Zymox® Topical Spray or Cream for HotSpots by Pet King Brands

Zymox by Pet King Brands

Zymox® Topical Spray or Cream for HotSpots by Pet King Brands Zymox

Wondering which dog skin care actually work for dogs?

Reviewed by Ann Pruitt, InfoHorse.com · Updated May 2026
Zymox Topical Spray with 1% Hydrocortisone 2oz bottle for dogs and cats by Pet King Brands
Zymox Topical Spray with 1% Hydrocortisone 2oz bottle for dogs and cats by Pet King Brands
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Zymox® Topical Spray or Cream for HotSpots by Pet King Brands
Zymox Topical Cream and Spray are ideal in wound care as well as other common skin conditions such as allergic skin and hotspots!
About Pet King Brands, Makers of Zymox®
Pet King Brands was started in 1998 by president and company visionary, Pamela Bosco and includes several products for pet dermatology and oral care. All of the products share a patented formulation of antimicrobial enzymes developed by Bosco's talented bioscientist brother, Michael Pellico. The LP3 Enzyme System is a combination of naturally occuring enzymes which work synergistically to form their antibacterial and antifungal properties and aid in the health of a pet’s ears, skin and mouth. The reigning flagship products continues to be the ZYMOX Ear products. Over the years, additional products have been introduced to meet the needs of pet owners seeking products without harsh chemicals or antibiotics and their availablity has been expanded to now include select pet retailers.


Relief Has Arrived— For Owners as Well as Dogs!

ZYMOX® not only brings relief to pets but to their owners as well. Nothing hurts a dog owner more than seeing their beloved dog suffer. Over time, chronic infections can be time-consuming, frustrating and extremely costly to a pet owner. ZYMOX®'s proven product line utilizes the LP3 Enzyme System for long-term maintenance and prevention of chronic ear and skin infections. These easy to use topical dermatology products are convenient, safe and effective.

Why Are Enzymes Better?

Enzymes are naturally occurring substances which act as catalysts to bring about a biochemical change. Enzymes won’t irritate a pet’s sensitive or raw skin; are very safe, non toxic for pets, people and the environment and most importantly, bacteria won’t develop resistance against enzymes. The patented LP3 Enzyme System in ZYMOX is a combination of enzymes which work synergistically to inhibit, split and destroy the offending bacteria, fungi and even some viruses making the combination antibacterial as well as antifungal. The enzymes only target the invading single-celled organisms, healthy cells are unaffected.

ZYMOX® Topical Spray or Cream for Hot Spots & Skin Infections!

The most common skin condition both dogs and cats can be afflicted with are hot spots. They are characterized by itchy, raw, sometimes bloody patches of skin. In addition to managing hot spots, the Zymox Topical Cream and Spray are ideal in wound care as well as other common skin conditions such as allergic skin..

Does It Matter What Kind Of Skin Infection or Hot Spots My Dog Has?

Regardless if bacterial, fungal or yeast, ZYMOX can be applied 1x/day as needed with no pre-cleaning or scrubbing of the skin because the LP3 Enzyme System reacts with the infectious pus and debris to form its antimicrobial properties and will naturally clean and disinfect the affected skin. ZYMOX is safe, gentle and non-toxic and worry-free if a pet licks application site. Both contain hydrocortisone for additional inflammation relief.

What About Hard To Reach Places on My Dog?

The TopicalCream features a catheter tip which is ideal for hard to reach applications such as skin folds and helps you target the application to whatever area your dog may be in need of receiving the soothing benefits of Zymox!

My Dog Has Ringworm— Can Zymox Help?

Yes, Zymox can help your dog overcome Ringworm, Impentigo, and yeast infections!

What About A Bathing Product To Help My Dog With Hot Spots and Skin Infections!

You will be glad to know that Zymox’s Shampoo and Conditioning Rinse is made specifically to sooth hot, itchy, miserable skin! We know that itchy skin is a serious discomfort and concern for your dog. He or she needs help NOW. You’ll love the way our Shampoo and Rinse leave your dog feeling both relieved, refreshed and smelling wonderful.

ZYMOX® Shampoo for Itchy Inflamed Skin

Zymox® Shampoo for Itchy Inflamed Skin is the first line of defense against infectious microbes is the skin. ZYMOX® Shampoo provides an effective way to protect this natural barrier without being irritating or drying. Only the mildest plant surfactants are used and the enzymes have anti inflammatory properties to calm the skin. The LP3 Enzyme System with the addition of Vitamin D3 helps relieve surface irritations and hydrate the skin. The shampoo contains no harsh detergents, chemicals or petroleum bi-products and features a pleasant, mild fragrance.

It is...
• Pure and gentle enough for puppies and kittens
• Does not contain harsh detergents, steroids, or petroleum by-products
• Calms and soothes itchy allergy prone skin
• Provides natural inflammation relief
• Pleasant mild fragrance

ZYMOX® Conditioning Rinse for Itchy Inflamed Skin

Zymox® Conditioning Rinse for Itchy Inflamed Skin produces a powerful protective barrier against minor skin inflammations and surface irritations due to bacterial and fungal microbes. The LP3 Enzyme System with Vitamin D3 provides optimal protection for the skin. For best results, wash first with ZYMOX® Shampoo and use as a leave-in rinse for residual effectiveness. Can also be safely applied full strength directly to most problematic areas.

Bio-active enzymes have been shown to be effective against:
• Pyotraumatic Dermatitis
• Trichopyton
• Pseudomonas
• Impetigo
• Candida Albicans
• Staphylococcus
• Bodyfold Pyoderma
• Malassezia
• Microsporum

Note: Use as a Leave On rinse for between bathing protection & relief.

What Do People Say Who Have Used Zymox®?


We started our dog on the Zymox® Shampoo and Rinse in July. This treatment made all the difference in the world.
—D. Baker El Dorado Springs, MO

I just called order the shampoo and rinse hoping it works on her skin allergies. Once I get those products I feel sure the skin problems will go away. I have so much faith in Zymox® I can't wait to get the products.
—N. Cox Mt. Juliet, TN

Don’t Let Your Dog Suffer a Minute Longer! Buy Zymox® Today!

Hot Spots, Itchy Skin and Wounds must be dealt with— and Zymox is the product to do it. You’ll love the affordability, the ease of use, but best of all, you’ll love the way it makes your dog feel— and look! Zymox is available at DrsFosterandSmith.com, JeffersPet, HorseHealthUSA, and distributors across the country!



Zymox Topical Spray with 1% Hydrocortisone 2oz bottle for dogs and cats by Pet King Brands
Zymox Topical Spray with 1% Hydrocortisone 2oz bottle for dogs and cats by Pet King Brands

What is the patented LP3 Enzyme System behind every Zymox formula?

Zromox products are built around the LP3 Enzyme System, a patented trio of naturally derived enzymes: lactoperoxidase, lysozyme, and lactoferrin. Rather than killing bacteria the way an antibiotic does, this enzyme system works at a cellular level to break down harmful, single-celled organisms while leaving healthy skin flora intact. Because it targets only harmful bacteria, fungus, and yeast, it minimizes the risk of bacterial resistance and the side effects often tied to medicated washes and antibiotics. The enzymes actually thrive in the presence of organic matter such as pus, wax, and discharge, so their antimicrobial activity intensifies exactly where an infection is worst.

Zymox Topical Spray with 0.5% Hydrocortisone 2oz anti-itch pet spray product
Zymox Topical Spray with 0.5% Hydrocortisone 2oz anti-itch pet spray product
Who makes Zymox, and what is the Pet King Brands story?
Zymox is made by Pet King Brands, Inc., founded in 1998 by president and company visionary Pamela Bosco. The company was inspired by the recovery of Bosco's German Shepherd from chronic ear infections, and the breakthrough LP3 Enzyme System was developed with her bioscientist brother, Michael Pellico. Pet King Brands is a leader in veterinarian-approved pet products made in the U.S., and beyond Zymox ear and skin care it also produces Oratene brushless oral care, Zylafen, and Equine Defense. The company specializes in pet dermatology and oral care formulated to be gentle, non-toxic, and worry-free.

Zymox Topical Spray without Hydrocortisone 2oz hydrocortisone-free pet wound care
Zymox Topical Spray without Hydrocortisone 2oz hydrocortisone-free pet wound care

How do Zymox Topical Cream and Topical Spray treat hot spots and wounds?

Zymox Topical Cream and Topical Spray are designed for wound care and for common skin conditions including hot spots, body-fold irritations, allergic skin, wounds, cuts, and skin infections caused by bacteria, fungus, or yeast. They are effective on troublesome conditions such as wet eczema, pyoderma, Staphylococcus, Mrsa, and ringworm, and are safe for dogs and cats of any age. The enzymatic action goes to work on the affected area while soothing aloe vera helps calm redness and inflammation. Both forms are available in a hydrocortisone-free version and in 0.5% and 1.0% hydrocortisone strengths to relieve the itching tied to inflammation and dermatitis.

Zymox Topical Spray 1% Hydrocortisone benefits chart LP3 Enzyme System hot spots
Zymox Topical Spray 1% Hydrocortisone benefits chart LP3 Enzyme System hot spots

Why does Zymox tell you to skip the painful pre-cleaning step?

Unlike most topical treatments, Zymox requires no pre-cleaning of the wound or skin before application. Pre-cleaning and washing during a course of treatment actually disrupts the enzymatic biological system and will negatively affect results, because the enzymes feed on the organic matter present in the infection. The recommended directions are to apply onto the affected area once or twice a day for up to seven days, leaving the formula in place to do its work. This makes treatment far less stressful for an animal already in discomfort from a sore, raw hot spot.

Is Zymox safe if my pet licks the treated area?

Yes. Zymox Topical Spray and Cream are formulated to be safe, gentle, non-toxic, and worry-free if a pet licks the application site. The LP3 enzymes are naturally derived from sustainable sources rather than harsh synthetic biocides, which is a key reason groomers, breeders, and veterinarians reach for the line. This makes it suitable for sensitive pets, including those prone to allergies, and removes the need for a cone or constant supervision after each application.

Where can you buy Zymox Topical products?

Zymox is sold directly through the brand's official online store at zymox.com, where the full Skin, Ear, and Oral Care lines are available. The products are also widely stocked by major pet retailers and online pharmacies including PetSmart, Petco, and Chewy, as well as veterinary clinics and professional groomers across the U.S. The Topical Spray and Topical Cream are commonly sold in convenient 2 oz and 1 oz sizes for at-home first-aid and dermatology use.

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The Solution Section (FAQ)
What is ZYMOX® and how does it work?
ZYMOX® by Pet King Brands is a line of topical pet dermatology products built around the patented LP3 Enzyme System. The LP3 system combines naturally occurring enzymes that work synergistically to inhibit, split and destroy offending bacteria, fungi and even some viruses, giving it both antibacterial and antifungal properties. The enzymes target only the invading single-celled organisms, so healthy cells are unaffected.
Can ZYMOX® treat my dog's hot spots?
Yes. Hot spots are one of the most common skin conditions in dogs and cats, showing up as itchy, raw, sometimes bloody patches of skin. ZYMOX® Topical Cream and Spray are made to manage hot spots and are also ideal for wound care and other skin conditions such as allergic skin. Both contain hydrocortisone for additional inflammation relief.
Do I need to clean or scrub the skin before applying ZYMOX®?
No. ZYMOX® Topical Cream and Spray can be applied once a day as needed with no pre-cleaning or scrubbing, because the LP3 Enzyme System reacts with the infectious pus and debris to form its antimicrobial properties and naturally clean and disinfect the affected skin. It works the same whether the infection is bacterial, fungal or yeast. It is also safe and worry-free if your pet licks the application site.
Why are enzymes better than harsh chemicals or antibiotics?
Enzymes are naturally occurring substances that act as catalysts to bring about a biochemical change without irritating sensitive or raw skin. They are non-toxic for pets, people and the environment, and bacteria won't develop resistance against them. That makes ZYMOX® a good option for pet owners seeking products without harsh chemicals or antibiotics.
How do I reach hard-to-treat areas like skin folds?
The ZYMOX® Topical Cream features a catheter tip designed for hard-to-reach applications such as skin folds. It lets you target the cream precisely to whatever area your dog needs, delivering the soothing benefits right where they're required.
Can ZYMOX® help with ringworm or yeast infections?
Yes. ZYMOX® can help your dog overcome ringworm, impetigo and yeast infections. Because the LP3 Enzyme System is both antibacterial and antifungal, it addresses skin issues regardless of whether they are bacterial, fungal or yeast in origin.
Is there a ZYMOX® bathing product for itchy, inflamed skin?
Yes. ZYMOX® Shampoo for Itchy Inflamed Skin uses only the mildest plant surfactants, with enzymes that have anti-inflammatory properties plus Vitamin D3 to help relieve surface irritations and hydrate the skin. It contains no harsh detergents, steroids or petroleum by-products and is gentle enough for puppies and kittens. Pair it with the ZYMOX® Conditioning Rinse, which can be used as a leave-in for residual protection between baths.
How can I learn more or find ZYMOX® products?
Pet King Brands, the maker of ZYMOX®, was founded in 1998 and offers several products for pet dermatology and oral care. You can explore the product line and find purchasing options at https://www.zymox.com, or call the company's friendly staff at 888-752-5847.
What is Zymox Topical Cream used for?
Zymox Topical Cream is used for wound care and for common skin conditions on dogs and cats of any age, including hot spots, body-fold irritations, wounds, cuts, and skin infections. It is effective against problems caused by bacteria, fungus, and yeast, such as wet eczema, pyoderma, Staphylococcus, MRSA, and ringworm. The cream uses the patented LP3 Enzyme System plus soothing aloe vera.
What is the difference between Zymox Topical Spray and Topical Cream?
Both use the same LP3 Enzyme System and treat the same conditions, but the format differs. The spray is convenient for larger or hard-to-reach areas and for animals that dislike being touched on a sore spot, while the cream is ideal for targeted application to a specific lesion, cut, or body fold. Both come in hydrocortisone-free, 0.5%, and 1.0% hydrocortisone versions.
What is the LP3 Enzyme System?
The LP3 Enzyme System is the patented technology at the heart of every Zymox product. It combines three naturally derived enzymes: lactoperoxidase, lysozyme, and lactoferrin. Together they work synergistically to break down harmful bacteria, fungi, and yeast at a cellular level while leaving healthy skin flora intact.
How is Zymox different from an antibiotic?
Antibiotics kill bacteria directly and can disrupt healthy flora, contributing to side effects and bacterial resistance. Zymox instead uses enzymes that target only harmful, single-celled organisms, which minimizes resistance risk and is gentler on the pet's skin and coat. The enzymes also thrive where organic matter like pus or wax is present, enhancing their antimicrobial activity exactly where it is needed.
Do I need to clean the wound before applying Zymox?
No, and you should not. Zymox is specifically designed so that no pre-cleaning is required, because the enzymes feed on the organic matter in the infection. Pre-cleaning or washing during a course of treatment disrupts the enzymatic biological system and will negatively affect the results.
Is Zymox safe if my pet licks the treated area?
Yes. Zymox Topical Spray and Cream are formulated to be safe, gentle, non-toxic, and worry-free if a pet licks the application site. This means you typically do not need a cone or constant supervision after applying it. It is suitable even for sensitive pets and those prone to allergies.
How often should I apply Zymox Topical Spray or Cream?
The recommended directions are to apply onto the affected area once or twice a day for up to seven days. The formula should be left in place rather than washed off, so the enzymes can continue working. If the condition does not improve, consult your veterinarian.
What hydrocortisone strengths does Zymox offer?
Zymox Topical products are available in three options: a hydrocortisone-free formula, a 0.5% hydrocortisone version, and a 1.0% hydrocortisone version. The hydrocortisone is included to calm irritated skin and relieve the itching associated with inflammation and dermatitis. All versions include the LP3 Enzyme System and soothing aloe vera.
Which Zymox version should I choose, hydrocortisone or hydrocortisone-free?
Choose a hydrocortisone version (0.5% or 1.0%) when the main concern is itching, redness, and inflammation, since the hydrocortisone and aloe help calm the skin. Choose the hydrocortisone-free formula when you want to manage a wound, cut, abrasion, or infection without a steroid, or for pets where hydrocortisone is not desired. When in doubt, ask your veterinarian which is most appropriate.
Who makes Zymox?
Zymox is made by Pet King Brands, Inc., a U.S.-based company that is a leader in veterinarian-approved pet products. The company was founded in 1998 by president and company visionary Pamela Bosco. Pet King Brands specializes in pet dermatology and oral care.
How did Pet King Brands and Zymox get started?
Pamela Bosco launched Pet King Brands in 1998, inspired by her own German Shepherd's recovery from chronic ear infections using enzyme-based technology. She developed the breakthrough LP3 Enzyme System with her bioscientist brother, Michael Pellico. That innovation became the foundation for the entire Zymox line of ear and skin products.
What other products does Pet King Brands make besides Zymox?
In addition to the Zymox ear and skin care lines, Pet King Brands makes Oratene brushless oral care for pets, as well as ZYLAFEN and Equine Defense. All of the company's products are made in the U.S. and built around its enzyme-based, veterinarian-approved approach to pet health.
Can Zymox be used on both dogs and cats?
Yes. Zymox Topical Spray and Topical Cream are safe for use on dogs and cats of any age. The brand also makes dedicated formulations such as Zymox for Cats and Kittens. Because the products are non-toxic and gentle, they are appropriate for sensitive and allergy-prone animals.
What skin conditions and infections does Zymox treat?
Zymox Topical products help manage hot spots, body-fold irritations, wounds, cuts, abrasions, and skin infections. They are effective against conditions caused by bacteria, fungus, and yeast, including wet eczema, pyoderma, Staphylococcus, MRSA, and ringworm. The enzymatic system targets the harmful organisms while aloe vera soothes the surrounding skin.
Is Zymox veterinarian recommended?
Yes. Pet King Brands is described as a leader in veterinarian-approved pet products, and Zymox is trusted by veterinarians, groomers, and breeders. Its enzyme-based, antibiotic-free approach and no-cleaning convenience are among the reasons professionals reach for it. As with any treatment, consult your own veterinarian for persistent or severe conditions.
Where can I buy Zymox Topical Spray and Cream?
Zymox is available directly from the brand's official online store at zymox.com, which carries the full Skin, Ear, and Oral Care lines. It is also widely stocked at major retailers and pharmacies including PetSmart, Petco, and Chewy, plus many veterinary clinics and professional groomers. The Topical Spray and Cream are commonly sold in 2 oz and 1 oz sizes.
Why do the Zymox enzymes work better where an infection is worst?
The LP3 enzymes are activated by organic matter such as pus, wax, and discharge, which are present in the highest concentration at the site of an active infection. As a result, the antimicrobial activity actually intensifies exactly where it is needed most. This is also why washing the area away during treatment is counterproductive.

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Ann Pruitt
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