GlycoGuard

GlycoGuard by Evolve Bio Systems GlycoGuard is the FIRST "VET RECOMMENDED"

Need a trusted source for horse immunity health for horses?

Reviewed by Ann Pruitt, InfoHorse.com · Updated April 2026

GlycoGuard by Evolve Bio Systems
GlycoGuard is the First "VET Recommended", Direct-Fed Microbial Gel Specifically Formulated For Nursing Foals!

Why Is A Healthy Gut So Important?

Your horse’s gut is the “engine” to your horse. It is where the immune system develops. Horses are no different than humans— when your gut does not feel well, you aren’t able to do well or to fight off infections properly— it is the same with your horse. An unhealthy digestive system throws everything off. All mammals immune systems starts in the gut, so lets keep the gut healthy! Glycoguard has no equal and is the best support you can give your foal or horses!

A Great Life Begins From Within! How GlycoGuard Supports Gut Health For Your Foal!
GlycoGuard provides foals with the key bacteria selected for the ability to help the foal maximize nutrition already available in mares milk. It is the only probiotic on the market that is clinically shown to effectively colonize and stabilize the foals gut from the start. GlycoGuard remodels the foals Microbiome to unlock the nutrient in the mares milk. Can be used as a preventive or a treatment for diarrhea in your foals. Most diarrhea related to C-Diff or foal heat. When used as preventive you are starting your foals guts off right by, putting the good bacteria in their guts from the very beginning.

It All Starts From Within!

So Why Choose GlycoGuard Over Any Other Probiotic For Your Foals?
Very simply, because GlycoGuard is the only probiotic on the market with live active bacteria. We are vet recommended direct-fed microbial probiotic. Its encapsulated bacteria so it is strong enough to get into the gut and colonize and do it magic. Also GlycoGuard is the only probiotic on the market that carries this strain of B Infantis. No one else can carry this strain! It is a human grade bacteria.

What Does GlycoGuard Do For My Foal That Is So Amazing?

GlycoGuard helps in foals development by allowing the foal to break down the fatty charbohydrate in the mares milk for maximum nutrition. So you get bigger and stronger foals from the start when using GlycoGuard. If the gut is not properly prepared, much of the nutrition in the mare’s milk can pass right through without becoming property utilized by the foal’s body. This ability to utilize the mare’s milk comes from the 2 key bacteria that is used in the GlycoGuard: Bifidobacterium and Lactobacillus, and converted to short-chain fatty acids. This amazing combination has created the only probiotic on the market that is clinically shown to effectively colonize and stabilize the foal's gut from the start!

So How Long Should My Foals Be On GlycoGuard?

Foals when using from the beginning of life its 1 tube per foal. Can be started as early as 6 hours after they are born. You want them to be nursing for at least 20 mins. There are 8 doses per tube. Each foal is given 10 cc 2 x day for 4 days. Sometime you may need a second tube for a foal. If they have been stressed, had surgery, mom passed away, or has been sick and on lots of antibiotics. When used as a treatment for diarrhea the dosing is the same 10 cc 2x day for 4 days. Glycoguard must be kept cold between dosing.

Note: When using on an adult horse or pony its 20 cc 2x day for 2 days and then to be given once a month or before stressful situation.

Can GlycoGuard Help Horses With Digestive Issues, Senior Horses or Horses In Recovery?
Everyday our horses are put in stressful situations wither it be blacksmith, vet, surgery, hauling, shows or competition it all effects there guts and how they perform and act. That’s where GlycoGuard can help to put the good bacteria in their guts and keep it there! GlycoGuard is the only probiotic on the market with live active bacteria. We are vet recommended direct-fed microbial probiotic. Its encapsulated bacteria so it is strong enough to get into the gut and colonize and do its magic. Also GlycoGuard is the only probiotic on the market that carries this strain of B Infantis. No one else can carry this strain! It is a human grade bacteria. For a happy and healthy horse or pony!

What About Rescue Horses?

So many people have rescue or horses that are poor keepers— many are drastically under weight with terribly taxed immune systems. Everyone asks “ Can Glycoguard help?”, and the answer is “yes”! GlycoGuard can help your horses achieve and maintain a healthy gut by putting the best combinations of healthy bacteria into the gut. It will help your horses to break down the fats in their feed for better nutrition absorption. Healthy guts truly mean healthy horses!

What Do Horse Owners Say About GlycoGuard?

Saving Minuteman— Not A Minute Too Early!

Minuteman was born 4 weeks early in the middle of the night. Some how after he was born he rolled under the fence and got separated from mom till the morning. So he did not get to nurse for 6 hours till morning when Sarah found him.. He was very thin and weak and unable to stand. Sarah had ordered glycoguard 2 days before to have on hand for when he was born. He was given glycoguard and after the 3 rd dose she said he was a different foal up and jumping around and acting like a normal foal. She also said Glycoguard has helped him to fill out..I had the pleasure of meeting this little guy when he was very sick. So sick he could not stand. It broke my heart. His mom had a ruptured placenta for 2 weeks before he was born so he Was not getting the nutrients he needed before he was born. So born very weak and small not expected to live said her vet . The owner had heard about Glycoguard bought a tube . He was on Med’s and fluids not doing well. He had revived his second dose of GlycoGuard and she called me in tears saying his jumping around the stall and nursing like nothing ever happened!!! I have attached a video and picture of him from yesterday. He is doing great and this is 2 days on GlycoGuard .Glycoguard is a time saver, a money saver and a life saver. Over the past couple of years, we’ve had a problem with neonatal foal diarrhea, specifically some cases of C. diff. Some of the diarrhea was serious enough to require hospitalization of the foal. This year, every single foal received a tube of Glycoguard beginning at birth and we did not have a single case of diarrhea. Most of the foals didn’t even show foal heat diarrhea. I’ve told every breeder I know to try it – it’s been a game changer for us. We will have Glycoguard in stock for every foaling season!

Overcoming Diarrhea— and Saving The Foal!

A foal at Upenn had diarrhea for weeks, along with a case of Salmonella, and nothing was working. The poor foal was getting weaker and weaker. I had spoken to Dr. Michelle about trying GlycoGuard. She agreed to try it and within 2 days the foal has solid poop for the first time in her short life. 3 weeks later she is doing great and going home. Thank you GlycoGuard!

Saving A Foal In Albany!

A small foal born early in Albany Wisconsin last month the vet reached out to me. The foal had C-diff and was on fluids and antibiotics and had chronic diarrhea and getting very weak. They had heard about GlycoGuard from another vet in area and wanted to give it a try since this foal was tanking pretty bad. It was after 2 days of Glycogurad the foal was doing much better and after a week was doing great!

A Reproductive Veterinarian Discovers GlycoGuard!

Dr. Ellen Thomas is a repro vet in Va and was having issues with diarrhea in her foals. She had heard about GlycoGuard from Piedmont Equine who was already using our product. She called me to order and wanted to see if this would work for her clinic. She had called me and said in the beginning she was in disbelief that it would work, just thought we were another probiotic. After using on 2 foals she called me and said we have an amazing product and it works she said he saw a difference in weight gain in the foals that used GlycoGuard.

Another Veterinarian’s Foal Saved By Glycoguard!

Dr. Cassey Mahoney’s foal was born septic and not doing well. She had used GlycoGuard and 12 days later her foal was doing great and going to grow up big and strong. She loves our product!! She used Glycoguard on all of her foals this yr.

Premie Foal Saved By GlycoGuard!

Renee Bambach had a foal born early that was not nursing at all. She was trying to bottle feed the foal but still not taking to it. As fast as it was going in it was coming out. Her vet told her to try GlycoGuard. After just 2 doses she saw a huge difference in her foal and after 1 week she was acting like a normal foal.

A Great Life Begins From Within! Order GlycoGuard Today!
The whole point of eating (nursing) is to bring nutrition to the body. If the foal can’t receive the nutrients from nursing, then nursing will not save the foal. Glycoguard is the First Vet-Recommended, direct-fed microbial gel specifically formulated for nursing foals and is making a real difference in their lives— like— giving them a life to have! That’s right, we’re taking credit for saving many lives. Order GlycoGuard today— 8 doses per syringe— and worth every darn dime! Let GlycoGuard make a real difference to the foals in your life and call Caitlyn to order Today!

What exactly is GlycoGuard and how is it different from an ordinary foal probiotic?
GlycoGuard® is an oral, direct-fed microbial gel formulated specifically for newborn nursing foals, not a repurposed general-livestock probiotic. It pairs two activated beneficial bacteria — Bifidobacterium infantis and Lactobacillus plantarum — that are uniquely suited to thrive on the sugars in mare's milk. The company describes it as the first and only clinically shown probiotic that effectively colonizes and stabilizes a foal's large intestine within 24 hours, working alongside the mare's milk rather than competing with it.

Who makes GlycoGuard and what is the company's background?

GlycoGuard is produced by Infinant Health, Inc., the company previously known as Evolve BioSystems, based in Davis, California. Evolve built its science around the activated B. infantis EVC001 strain that it first developed to remodel the newborn human-infant gut microbiome, then carried that same gut-colonization expertise into the animal-health market with GlycoGuard for foals. The company's research has drawn investment from leading institutions including the Bill & Melinda Gates Foundation, Johnson & Johnson, and Cargill, signaling unusually deep scientific pedigree for an equine supplement.

What is inside the gel and why those specific bacterial strains?

The patented formula is built on activated Bifidobacterium infantis (B. longum subsp. infantis) plus Lactobacillus plantarum. These strains are chosen because they can break down the complex carbohydrates in mare's milk, which lets them establish quickly and crowd out the conditions that lead to gut dysbiosis. The "activated" preparation is what allows the bacteria to begin colonizing immediately rather than passing through, which is central to the 24-hour colonization claim.

How does GlycoGuard actually work inside the newborn foal?

When fed orally at birth, GlycoGuard delivers its bacteria straight to the foal's digestive tract, where they rapidly colonize and stabilize the large intestine and begin fermenting milk sugars into beneficial short-chain fatty acids. That short-chain fatty acid production helps strengthen the gut barrier, improves nutrient absorption from the mare's milk, and supports immune-system development during the critical first weeks of life. The net effect the company describes is a healthier, more diverse gut microbiome and a reduced risk of the gastrointestinal disturbances that commonly trouble young foals.

Which foals is GlycoGuard intended for, and is it veterinarian recommended?
GlycoGuard is intended for nursing foals starting at birth, the window when the gut microbiome is first establishing itself and is most vulnerable. It is positioned as a vet-recommended, breeder- and trainer-trusted protocol for routine newborn-foal care; practitioners such as Dr. Cassy Mahoney of Farmview Veterinary Services and Martin Veterinary Services have publicly endorsed using it as part of standard foaling protocols. Breeders aiming to give every foal the strongest possible start, and operations managing valuable bloodstock, are the core audience.

How do you dose GlycoGuard, and how do you buy it?
GlycoGuard ships as a pre-measured oral dial-a-dose syringe, with one syringe providing 8 servings. The directions are to turn the dial to the correct marking, insert the tip into the foal's mouth, and depress the plunger; one 10 cc serving is given orally at birth and then every 12 hours for 4 consecutive days, for 8 total feedings. You can order directly from the official site at www.glycoguard.com, and questions or reorders can be handled by phone at (844) 463-8486.

Share This Solution

Facebook X LinkedIn Email

The Solution Section (FAQ)

What is GlycoGuard and what is it used for?

GlycoGuard by Evolve Bio Systems is a vet-recommended, direct-fed microbial gel formulated specifically for nursing foals. It puts beneficial bacteria into the foal's gut from the start, helping the foal break down the fatty carbohydrates in the mare's milk for maximum nutrition. It can be used preventively or as a treatment for foal diarrhea.

Why is gut health so important for a foal or horse?

The gut is described as the engine of the horse and is where the immune system develops. In all mammals the immune system starts in the gut, so an unhealthy digestive system throws everything off. GlycoGuard supports a healthy gut so the foal or horse can absorb nutrition and fight off infection.

What makes GlycoGuard different from other horse probiotics?

GlycoGuard is described as the only probiotic on the market with live active bacteria, using encapsulated bacteria strong enough to reach the gut, colonize, and stabilize it. It is also the only probiotic carrying its particular strain of B. infantis, a human-grade bacteria. Its two key bacteria, Bifidobacterium and Lactobacillus, are converted to short-chain fatty acids the foal can use.

How do I dose GlycoGuard for a newborn foal?

For foals used from the beginning of life it is one tube per foal, with 8 doses per tube. Each foal gets 10 cc twice a day for 4 days, and it can be started as early as 6 hours after birth once the foal has been nursing for at least 20 minutes. A stressed, sick, orphaned, or post-surgery foal may need a second tube.

Can GlycoGuard be used on adult horses, senior horses, or rescues?

Yes. For an adult horse or pony the dose is 20 cc twice a day for 2 days, then given once a month or before a stressful situation such as the blacksmith, vet, hauling, shows, or competition. It can also help senior horses, horses in recovery, and underweight rescue horses absorb the fats in their feed for better nutrition.

Does GlycoGuard help with foal diarrhea?

Yes. It can be used to treat diarrhea in foals, including cases related to C. diff or foal heat, at the same 10 cc twice a day for 4 days. Used preventively from birth, it helps establish good bacteria in the foal's gut so problems are less likely to start.

How should GlycoGuard be stored?

GlycoGuard must be kept cold between dosing. Because it is a live active bacteria product, keep it cold between doses so it is ready when given to your foal or horse.

How do I order GlycoGuard or get more information?

You can order or learn more by visiting https://www.glycoguard.com or calling Caitlyn at 610-246-2073. The team can help you decide whether to use GlycoGuard preventively from birth or as a treatment for your foal or horse.

What is GlycoGuard?

GlycoGuard® is an oral, direct-fed microbial (probiotic) gel made specifically for newborn nursing foals. It contains two activated beneficial bacteria, Bifidobacterium infantis and Lactobacillus plantarum, that work together with mare's milk to establish a healthy gut microbiome in the foal's first days of life. It is the first such product positioned as a vet-recommended foal gut-health protocol from Infinant Health (formerly Evolve BioSystems).

Who manufactures GlycoGuard?

GlycoGuard is made by Infinant Health, Inc., the company formerly known as Evolve BioSystems, based in Davis, California. The company originally developed activated B. infantis science for the human-infant gut microbiome and then entered the animal-health market with GlycoGuard for foals. Its research has been backed by investors including the Bill & Melinda Gates Foundation, Johnson & Johnson, and Cargill.

What bacterial strains are in GlycoGuard?

GlycoGuard's patented formula is built on activated Bifidobacterium infantis (Bifidobacterium longum subsp. infantis) together with Lactobacillus plantarum. These two strains were selected because they can break down the complex carbohydrates found in mare's milk, allowing them to colonize the foal's gut quickly. The 'activated' preparation lets the bacteria begin working immediately rather than passing through the digestive tract.

How does GlycoGuard work in a newborn foal?

When fed orally at birth, GlycoGuard delivers its bacteria directly to the foal's digestive system, where they rapidly colonize and stabilize the large intestine. The bacteria ferment milk sugars into beneficial short-chain fatty acids, which strengthen the gut barrier and improve nutrient absorption from the mare's milk. This helps support immune development and reduces the risk of gastrointestinal upset during the foal's critical early weeks.

How fast does GlycoGuard colonize the foal's gut?

The company states that GlycoGuard is the only clinically shown probiotic that effectively colonizes and stabilizes the nursing foal's large intestine within 24 hours. Provided immediately after birth, it works alongside mare's milk to properly establish intestinal microflora during the first few weeks of life. This rapid colonization is the central benefit that distinguishes it from generic probiotics.

How do you give GlycoGuard to a foal?

GlycoGuard comes in a pre-measured oral dial-a-dose syringe. You turn the dial to the appropriate marking, insert the tip into the foal's mouth, and depress the plunger until it stops. Each serving is 10 cc given by mouth, making administration quick and simple in the foaling stall.

What is the recommended GlycoGuard dosing schedule?

The directions are to feed one 10 cc serving orally at birth and then every 12 hours for 4 consecutive days, for a total of 8 feedings. One syringe of GlycoGuard provides those 8 servings, covering the full recommended protocol for a single foal. Beginning at birth is important because that is when the gut microbiome first establishes itself.

How many servings come in one GlycoGuard syringe?

One GlycoGuard syringe contains 8 servings, with each serving being 10 cc. That is exactly enough to complete the full recommended protocol of one dose at birth plus a dose every 12 hours for four days. Operations foaling multiple mares will want one syringe per foal.

Is GlycoGuard veterinarian recommended?

Yes. GlycoGuard is marketed as a vet-recommended product, and several practitioners have publicly endorsed it. Dr. Cassy Mahoney of Farmview Veterinary Services has described using GlycoGuard as part of routine newborn-foal care, and Martin Veterinary Services has also provided a testimonial. It is positioned as a tool breeders and veterinarians can fold into standard foaling protocols.

When should I give GlycoGuard to my foal?

GlycoGuard is designed to be given starting at birth, with the first dose as soon after foaling as practical. This timing matters because the newborn gut microbiome is first establishing itself in the earliest hours and days of life, and that is the window in which GlycoGuard's bacteria can colonize most effectively. The protocol then continues every 12 hours for four days.

What benefits does GlycoGuard provide for foals?

By rapidly colonizing and stabilizing the foal's gut, GlycoGuard helps maximize nutrient absorption from mare's milk, increases beneficial short-chain fatty acid production, and improves gut barrier function. These effects support immune-system development and reduce the risk of gastrointestinal disturbances. The overall goal is a healthier, more diverse gut microbiome that gives the foal a strong start toward peak growth and performance.

Does GlycoGuard help with foal digestive problems?

GlycoGuard is intended to support healthy gut development and reduce the risk of gastrointestinal disturbances by establishing beneficial bacteria early. By improving the gut barrier and helping the foal break down and absorb nutrients from mare's milk, it supports more stable digestion during a vulnerable period. For any active illness or sick foal, you should consult your veterinarian, as GlycoGuard is a preventive gut-health support, not a treatment for disease.

Where is GlycoGuard sold and how do I order it?

GlycoGuard can be ordered directly from the official website at www.glycoguard.com. The product is sold by Infinant Health (formerly Evolve BioSystems), based in Davis, California. Customer questions and reorders can also be handled by phone.

What is the phone number for GlycoGuard?

GlycoGuard can be reached at (844) 463-8486 for product questions, ordering, and customer support. You can also visit www.glycoguard.com for ordering and additional product information. The company is based in Davis, California.

Is GlycoGuard backed by science or clinical research?

Yes. GlycoGuard grew out of Evolve BioSystems' research on activated B. infantis EVC001, a strain extensively studied for remodeling the newborn human-infant gut microbiome. The company describes GlycoGuard as the only clinically shown probiotic that colonizes and stabilizes the foal's large intestine within 24 hours and as having a patented formula. Its scientific foundation and high-profile institutional investors set it apart from typical supplements.

Who is the ideal customer for GlycoGuard?

GlycoGuard is ideal for horse breeders, foaling operations, and owners who want to give every newborn foal the strongest possible start in life. It is especially relevant for valuable bloodstock and performance prospects where early gut health and immune development carry long-term value. Veterinarians who manage foaling clients also use it as part of routine newborn protocols.