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Anhidrosis Prevention By ONE AC — Health (Anhidrosis-the partial or total inability to sweat-has been recognized in…)

Anhidrosis Prevention By ONE AC

Anhidrosis-the partial or total inability to sweat-has been recognized in horses since the early

Got a horse that can't sweat properly in the heat and needs anhidrosis support?

Reviewed by Ann Pruitt, InfoHorse.com · Updated May 2026
Anhidrosis Prevention By ONE AC — Health (Anhidrosis-the partial or total inability to sweat-has been recognized in…)
Anhidrosis Prevention By ONE AC — Health (Anhidrosis-the partial or total inability to sweat-has been recognized in…)
Anhidrosis Prevention By ONE AC
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Anhidrosis Prevention By ONE AC
Help prevent the symptoms of Anhidrosis with One AC!

What Is Anhidrosis?

Anhidrosis-the partial or total inability to sweat-has been recognized in horses since the early 1920s. No definite reason has been discovered as to why some horses develop the problem, which can affect all ages and breeds. Anhidrosis is most commonly seen in horses living in America's Gulf Coast states, including Florida and Louisiana, and in South Texas.

What Causes Anhidrosis?
The ability to sweat is an essential physiological response in your horse if it is to perform in hot and humid climates. This ability to sweat allows your animal to maintain their interior core temperature at such a point so as not to interfere with their enzyme driven metabolic processes, which are also of an essential nature. Anhidrosis is a result of excess stress. By adding the additional stress of high temperature and humidity to an already stressful environment of training, some animals just can not produce sufficient dopamine to satisfy its needs. When this imbalance occurs, your horse begins to suffer the debilitating effects Anhidrosis.

What Is One AC And How Can It Help Prevent Anhidrosis?

One AC is a supplement based on the theory of imbalance of dopamine to the nor-adrenaline/adrenaline complex. Dopamine is used first by the brain, then by the cardiovascular system and last by the sweating system. A reduction in dopamine below a certain level allows the well-known vasoconstrictive properties of the nor-adrenaline/adrenaline complex to predominate and reduce the blood carrying capacity of the peripheral vascular system to a minimum, thereby reducing the ability of the sweat glands to function properly.

What Customers Say

Thanks again for this wonderful product! It really, really works great! Dana Hopkins Thank you so much, the powder is s true lifesaver for my thoroughbred boy! Carey Sweet I have used One AC for two years and it works so well. I tried to stop using it one summer and my horse was suffering. He was so hot and puffing that I went back on the product and my horse was like a new horse. Great product! Thank you. Linda Howell

What Sets One AC Apart From Other Anhdrosis Treatments?

It works! It was field tested at Florida State University in Gainesville in early 1994. All the horses in the test program responded well to the One AC. There were no ill effects on the pregnant mares and healthy foals were delivered. One AC was developed specifically to help the non-sweater thermo regulate. Non-sweating is caused by the shutdown of the peripheral vascular system caused by nor-adrenaline and adrenalin (flight or fight syndrome). Portions of the metabolate are used by the thyroid gland to produce T-4 and T-3. Horses with anhidrosis test hypo-thyroid.

Does One AC Have Any Side Effects And How Do I Use It?

One AC is a natural product and there are no side effects to contend with. It can be used indefinitely during the hot humid weather, which brings on anhidrosis. It is recommended to feed One AC twice a day as it is a food. Depending on the extent to which the horse is involved with the anhidrosis, some folks will feed only once a day or every other day during the cooler months as a way to "keep the pump primed".

Order One AC Today!

Don’t let your horse suffer the debilitating effects of Anhidrosis, visit us or find us at SmartPakEquine, ValleyVet, DoverSaddlery, JeffersEquine -- or your local tack store Today!




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The Solution Section (FAQ)
What is anhidrosis in horses?
Anhidrosis is the partial or total inability to sweat, and it has been recognized in horses since the early 1920s. No definite reason has been discovered as to why some horses develop the problem, which can affect all ages and breeds. It is most commonly seen in horses living in America's Gulf Coast states, including Florida and Louisiana, and in South Texas.
Why is it dangerous when a horse can't sweat?
Sweating is an essential physiological response that lets a horse perform in hot, humid climates. It allows the animal to hold its interior core temperature at a point that does not interfere with the enzyme-driven metabolic processes the horse depends on. When a horse loses the ability to sweat, that temperature regulation breaks down and the horse begins to suffer the debilitating effects of anhidrosis.
What causes a horse to stop sweating?
Anhidrosis is a result of excess stress. When the added stress of high temperature and humidity is layered onto an already stressful training environment, some horses simply cannot produce sufficient dopamine to satisfy their needs. Dopamine is used first by the brain, then the cardiovascular system, and last by the sweating system, so once it drops below a certain level the vasoconstrictive nor-adrenaline/adrenaline complex predominates and the sweat glands can no longer function properly.
What is One AC and how does it help a non-sweating horse?
One AC is a supplement built on the theory of an imbalance of dopamine to the nor-adrenaline/adrenaline complex. It was developed specifically to help the non-sweater thermoregulate, since non-sweating is caused by the shutdown of the peripheral vascular system driven by the flight-or-fight response. Portions of the metabolate are used by the thyroid gland to produce T-4 and T-3, which matters because horses with anhidrosis test hypothyroid.
Has One AC actually been tested, and does it work?
Yes. One AC was field tested at Florida State University in Gainesville in early 1994, and all of the horses in the test program responded well to it. There were no ill effects on the pregnant mares in the program, and healthy foals were delivered.
Does One AC have side effects, and how do I feed it?
One AC is a natural product, so there are no side effects to contend with. It is recommended to feed it twice a day because it is a food, and it can be used indefinitely during the hot, humid weather that brings on anhidrosis. Depending on how severely the horse is affected, some owners feed it only once a day or every other day during the cooler months as a way to keep the pump primed.
Where can I buy One AC?
You can visit One AC directly or find it at SmartPakEquine, ValleyVet, DoverSaddlery, and JeffersEquine, or at your local tack store.
How do I order One AC or ask a question about anhidrosis?
You can reach Missy to discuss your horse's anhidrosis and how to start on One AC. Call 602-866-7701, email MpCo@NonSweater.com, or visit http://www.nonsweater.com/ to order and learn more before the hot, humid season sets in.

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Ann Pruitt
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