Pro-Tect™ Antimicrobial Thrush Treatment

Pro-Tect™ Antimicrobial Thrush Treatment — beyond everyday hoof care.

Got a horse with stubborn thrush and want a natural water-based antimicrobial treatment?

Reviewed by Ann Pruitt, InfoHorse.com · Updated June 2026

Pro-Tect™ Antimicrobial Thrush Treatment

Pro-Tect™ Antimicrobial Thrush Treatment by Straight Arrow Products

Pro-Tect™ Antimicrobial Thrush Treatment goes beyond the every day thrush treatments typically seen in todays market.

Pro-Tect™ Antimicrobial Thrush Treatment

Thrush Treatment goes beyond the everyday thrush treatment on the market today.Pro-Tect™ Antimicrobial Thrush Treatment's exclusive natural water based formula eliminates organisms associated with thrush and other hoof related diseases.

Provides full and complete treatment for the entire hoof
Deep penetrating gel formula assures complete and effective treatment
Kills the bacteria associated with thrush
Kills other opportunistic bacteria and fungi
Non-drying, non-flammable, non-staining
Pleasant fragrance

Where Can I Buy Pro-Tect Antimicrobial Thrush Treatment?
All Straight Arrow products are available
JeffersEquine, ValleyVet, DoverSaddlery, SmartPak
and at most feed and tack stores- so be sure to pick up yours today!

What exactly is Pro-Tect® Antimicrobial Thrush Treatment?

Pro-Tect® Antimicrobial Thrush Treatment is a 16 oz. veterinary-strength topical liquid that targets thrush and other hoof-related diseases at the source. Rather than masking the problem, it eliminates the organisms associated with thrush using a deep-penetrating, water-based formula that works its way into the frog, sulci, and crevices where anaerobic bacteria thrive. It is part of the broader Pro-Tect® antimicrobial system from The Original Mane 'n Tail® Animal Care, alongside the Pro-Tect Medicated Shampoo and Skin & Wound Spray.

Mane 'n Tail Pro-Tect Veterinary Strength Medicated Shampoo and Spray antimicrobial set

Who makes it, and what's the company behind the brand?
The treatment is manufactured by Straight Arrow Products, Inc., the company behind The Original Mane 'n Tail® whose motto is "Serving our Customers with Tradition, Technology and Trust." Straight Arrow's portfolio spans Mane 'n Tail equine and personal-care lines, Cowboy Magic®, Exhibitor's, and Straight Arrow Therapeutic products. The Mane 'n Tail name began in the horse barn before crossing over to human hair care, giving the equine line decades of real-world stable credibility. For product questions, the company's animal-care line can be reached.

Mane 'n Tail ProTect Antimicrobial Medicated Shampoo 32 oz front by Straight Arrow

What's in it, and how does the antimicrobial action work?
The active ingredient is Benzalkonium chloride 0.75%, carried in Straight Arrow's exclusive Quatracin™ conditioning base. Benzalkonium chloride is a broad-spectrum quaternary-ammonium antimicrobial that disrupts the cell membranes of the bacteria and opportunistic fungi behind thrush, while the conditioning base keeps the formula from drying out healthy hoof and skin tissue. The result is a treatment that is non-drying, non-flammable, and non-staining, with a pleasant fragrance rather than the harsh, burning sting of traditional copper- or iodine-based thrush products.

Mane 'n Tail ProTect Antimicrobial Medicated Shampoo 32 oz label back with directions

How do you actually use it on a thrushy hoof?

The label directions are direct: "Clean the hoof thoroughly of dirt and debris. Apply Pro-Tect Antimicrobial Thrush Treatment directly onto hoof. Apply daily to all crevices and skin areas to assure thorough coverage. Massage in where possible with hands or, if preferred, a brush. Leave product on the hoof. Do not wash off." Because the formula is left on rather than rinsed, it keeps working between applications. It is labeled for external veterinary use on horses and other animals with hoof problems, but is NOT for use on cats or puppies.

Why do horse owners reach for Pro-Tect instead of an old-school thrush remedy?

Many classic thrush treatments rely on caustic chemicals that stain everything they touch, smell strongly, and can burn or dry sensitive frog tissue. Pro-Tect was built to go beyond those everyday treatments: it kills the bacteria associated with thrush and other opportunistic bacteria and fungi while staying gentle enough for daily use, won't stain hands or barn aisles, and carries a tolerable scent. For owners managing recurring thrush in wet, muddy footing, a non-burning daily-use option that can be left on the hoof is a meaningful upgrade.

How do you buy it, and what does it cost?
Pro-Tect Antimicrobial Thrush Treatment is sold as a 16 oz. bottle (SKU 70-064) and has retailed around $11.60 through farrier and tack suppliers such as Anvil Brand. The full Mane 'n Tail Pro-Tect antimicrobial line is showcased at manentailequine.com, and the products are widely carried by equine and farrier retailers. Because availability can vary by season and supplier, owners managing an active thrush case should confirm current stock with their preferred tack store or call Straight Arrow's animal-care line.

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The Solution Section (FAQ)

What is Pro-Tect™ Antimicrobial Thrush Treatment?

Pro-Tect™ Antimicrobial Thrush Treatment is a hoof-care product made by Straight Arrow Products. It uses an exclusive natural water-based formula to eliminate the organisms associated with thrush and other hoof-related diseases, going beyond the everyday thrush treatments on the market today.

How does Pro-Tect™ work on thrush?

Pro-Tect™ uses a deep-penetrating gel formula that reaches the entire hoof for complete, effective treatment. It kills the bacteria associated with thrush as well as other opportunistic bacteria and fungi.

Does Pro-Tect™ treat the whole hoof or just the affected spot?

It is designed to provide full and complete treatment for the entire hoof. The deep-penetrating gel helps assure thorough coverage rather than just surface contact.

Will Pro-Tect™ dry out, stain, or smell bad on my horse's hoof?

No. Pro-Tect™ Antimicrobial Thrush Treatment is non-drying, non-flammable, and non-staining, and it has a pleasant fragrance.

Who makes Pro-Tect™ Antimicrobial Thrush Treatment?

It is made by Straight Arrow Products, based at 900 Conroy Place, Easton, Pennsylvania 18040. All Straight Arrow products are available at most feed and tack stores.

Where can I buy Pro-Tect™ Antimicrobial Thrush Treatment?

All Straight Arrow products are available through retailers including JeffersEquine, ValleyVet, DoverSaddlery, and SmartPak, as well as most feed and tack stores. Be sure to pick up yours today.

How can I learn more or ask a question about Pro-Tect™ Antimicrobial Thrush Treatment?

You can reach Straight Arrow Products directly by phone at 1-800-827-9815 or by email at [email protected]. They can answer questions about Pro-Tect™ and help you find a retailer near you.

What is Pro-Tect Antimicrobial Thrush Treatment used for?

It is a topical hoof treatment for horses (and other animals) that targets thrush and other hoof-related diseases. The exclusive natural water-based formula eliminates the organisms associated with thrush, killing the bacteria and opportunistic fungi that infect the frog and hoof crevices. It is designed to provide full and complete treatment for the entire hoof rather than just masking the smell.

What is the active ingredient in Pro-Tect Thrush Treatment?

The active ingredient is Benzalkonium chloride 0.75%, carried in Straight Arrow's exclusive Quatracin conditioning base. Benzalkonium chloride is a broad-spectrum quaternary-ammonium antimicrobial that destroys the cell membranes of the bacteria and fungi responsible for thrush. The conditioning base helps keep the formula from drying out healthy hoof tissue.

How do you apply Pro-Tect Thrush Treatment to a horse's hoof?

Per the label: clean the hoof thoroughly of dirt and debris, then apply Pro-Tect Antimicrobial Thrush Treatment directly onto the hoof. Apply daily to all crevices and skin areas to assure thorough coverage, massaging it in where possible with your hands or a brush. Leave the product on the hoof and do not wash it off.

How often should I use Pro-Tect Thrush Treatment?

The directions call for daily application until the thrush is resolved. Because the formula is left on the hoof rather than rinsed off, it continues working between treatments. For stubborn or recurring cases, consult your farrier or veterinarian about how long to continue.

Will Pro-Tect Thrush Treatment burn or sting my horse?

No. Unlike many traditional thrush remedies, Pro-Tect is formulated to be non-drying and will not burn or cause irritation. It is non-flammable, non-staining, and has a pleasant fragrance, which makes daily application easier on both the horse and the handler.

Does Pro-Tect Thrush Treatment stain like copper sulfate or iodine products?

No. The formula is specifically described as non-staining, so it won't leave the dark marks on hands, clothing, and barn aisles that copper- and iodine-based thrush treatments are known for. This is one of the main reasons owners choose it over old-school remedies.

What size does Pro-Tect Thrush Treatment come in and what does it cost?

It is sold as a 16 oz. bottle (SKU 70-064) and has retailed for around $11.60 through farrier and tack suppliers such as Anvil Brand. Pricing and availability vary by retailer, so check current stock with your preferred tack store.

Where can I buy Pro-Tect Thrush Treatment?

The Mane 'n Tail Pro-Tect antimicrobial line is featured at manentailequine.com and the products are carried by many equine and farrier retailers, including Anvil Brand and DoMyOwn. You can also call Straight Arrow's animal-care line at 1-800-827-9815 for product and availability questions.

Is Pro-Tect Thrush Treatment safe for all animals?

It is labeled for external veterinary use on horses and other animals with hoof problems, but it is NOT for use on cats or puppies. As with any medicated product, keep it out of the reach of children and consult a veterinarian if any problems persist or are of concern.

What causes thrush in horses, and how does Pro-Tect address it?

Thrush is a bacterial and fungal infection of the frog, most common in horses kept in wet, muddy, or unsanitary footing where anaerobic organisms thrive in the hoof's grooves. It produces a black, foul-smelling discharge and can cause lameness if it reaches sensitive tissue. Pro-Tect's deep-penetrating, water-based formula reaches into those crevices to eliminate the organisms responsible.

Can Pro-Tect Thrush Treatment be used preventively?

Because it is gentle, non-drying, and meant to be left on the hoof, many owners use it as part of a regular hoof-care routine in wet or muddy conditions where thrush risk is high. Pairing daily picking-out and a clean, dry environment with routine treatment helps keep opportunistic bacteria and fungi from taking hold.

Should I mix Pro-Tect with other thrush treatments?

No. The label specifically warns: do not mix with other medicated thrush treatments. Combining products can reduce effectiveness or cause unintended reactions, so use Pro-Tect on its own and consult a veterinarian if the condition does not improve.

How is Pro-Tect different from the Mane 'n Tail Pro-Tect Shampoo and Spray?

All three share the same antimicrobial philosophy, but they target different areas. The Thrush Treatment is formulated specifically for hooves and the frog, while the Pro-Tect Antimicrobial Medicated Shampoo cleans and treats topical skin problems like rain rot, scratches, ringworm, and hot spots, and the Pro-Tect Skin & Wound Spray kills microorganisms on cuts and wounds. Together they form a complete Pro-Tect skin, wound, and hoof system.

What does 'antimicrobial' mean for this product?

Antimicrobial means the product is designed to kill or inhibit a broad range of microorganisms, including the bacteria, yeast, mold, and fungi that cause infections. In Pro-Tect Thrush Treatment, the benzalkonium chloride active ingredient delivers that broad-spectrum action against the specific organisms associated with thrush and other hoof diseases.

Is Pro-Tect Thrush Treatment flammable or harsh to store?

No. It is a water-based, non-flammable formula, which makes it safer to store and handle around the barn than alcohol- or solvent-based products. Keep the bottle closed, store it out of the reach of children, and follow standard label precautions.

Does Pro-Tect Thrush Treatment have a strong odor?

No. Instead of the sharp chemical smell typical of many thrush products, Pro-Tect is formulated with a pleasant fragrance. Combined with its non-staining, non-burning properties, this makes daily treatment far more pleasant for both horse and handler.